• Buying Guides

Best Midsize Luxury Sedans for 2021

By Andra DelMonico | May 4, 2021

Isn’t it time you traded in that economy subcompact or compact car and upgraded to a new car? You don’t have to go physically larger with a hatchback or crossover. You’ll find that the best luxury size sedans offer an enjoyable driving experience.

These comfortable cars offer roomy interiors, plenty of standard features, impressive fuel economy, and plenty of tech features. Say goodbye to the Lexus GS and Lincoln MKZ as 2020 was the last model year for these vehicles. This list of the best cars in 2021 will help you choose from the top mid-range size sedans.

1. 2021 Jaguar XF


There are two model options to choose from, the XF and XF R-Dynamic. The XF is a 2.0-liter four-cylinder engine that produces 246 horsepower. The XF R-Dynamic has the same engine but produces 296 horsepower. The XF is rear-wheel-drive, while the R-Dynamic is all-wheel-drive.


Both XF models are packed with technology and features. From the heated, electric, power fold, and memory door mirrors to the electrically adjustable steering column, you’ll find the XF to deliver a comfortable and quiet ride. The infotainment system is intuitive, and there’s an acceptable amount of cargo space in the trunk at 10.5 cubic feet. The MSRP starts at $43,995 for the Jaguar XF 2021 model.

Browse 2021 Jaguar XF listings here.

2. 2021 Mercedes-Benz E-Class


The E-Class sedan is a downsized version of the S-Class without sacrificing style or comfort. It delivers a strong and smooth ride with a peaceful interior environment. There are also plenty of innovative technology features throughout. The 2021 sedan comes with a new steering wheel design, front and rear styling, and an updated infotainment system.


There are two engine options for the E-Class: A 2.0-liter Inline four-turbo engine or the 3.0-liter inline-six turbo engine with EQ Boost.

Both engine options are paired with a 9G-TRONIC 9-Speed automatic transmission.

The E-Class stands out with a 64-color ambient lighting system and 12.3” digital instrument cluster, and touchscreen multimedia display.

It’s available as a four-door sedan or two-door coupe and cabriolet. The trunk space measures 9.5 cubic feet but can expand to 35 or 64 cubic feet, depending on the model you choose. The pricing for the Mercedes-Benz E-Class 2021 model starts at $63,050.

Browse 2021 Mercedes-Benz E-Class listings here.

3. 2021 Maserati Ghibli


Another great midsize luxury car, the five-seat 2021 Maserati Ghibli, features an elegant profile. New for the 2021 year is an optional high-performance 580 horsepower V8 engine, giving more of a sports sedan feel.

It also now comes with a 10.1-inch touchscreen infotainment standard.

The base 3.0-liter twin-turbo V6 engine is the carryover from the previous year. It comes standard with this car and can generate 345 horsepower and 369 foot-pounds of torque.


The stereo system is a standout feature for the Ghibli with a standard eight-speaker system. There are two upgraded systems available with ten and 15 speakers, respectively. The Ghibli has an impressive amount of trunk space at 17.66 cubic feet.

Pricing for the 2021 Maserati Ghibli starts at $73,685.

Browse 2021 Maserati Ghibli listings here.

4. 2021 Cadillac CT5


Part of the third generation of Cadillac CT5 midsize luxury sedans, the 2021 CT5 sports a powerful 2.0-liter twin-scroll turbocharged engine or a 3.0-liter twin-turbocharged V6 engine.

There are three trim packages available, the ES, ES F Sport, and ES Hybrid. Drivers appreciate the vehicle’s smooth acceleration and precise handling, noting that the car never wobbles when taking sharp turns.


This five-seat 2021 Cadillac CT5 comes with a ten-inch HD touchscreen central console and an optional AWD system. There are over 20 available driver assistance safety features.

Super Cruise also makes an appearance for the first time for a true hands-free driver-assistance system. The CT5 has a decent amount of trunk space at 11.9 cubic feet.

Pricing for the 2021 Cadillac CT5 starts at $36.995.

Browse 2021 Cadillac CT5 listings here.

5. 2022 Lexus ES


The latest model of the Lexus ES features a relaxing and quiet cabin with quality materials and an attractive starting price. New for the 2022 year is a light refresh to the car’s exterior styling. The infotainment screen is now a touchscreen and moved closer to the driver for easier access. Those who want to maximize mpg can now order the ES in a hybrid version.


You’ll appreciate how plush this luxury sedan feels; it's a favorite of ours here at Autolist.

There are three ES models available: the ES250, ES350, and ES300h.

The 250 has a 203 horsepower 2.5-liter four-cylinder engine, the 350 a 302 horsepower 3.5-liter V6 engine, and the 300h a 215 horsepower hybrid option. You’ll also appreciate the spacious trunk that measures 13.9 cubic feet.

Pricing for the 2021 Lexus ES starts at $40,000.

Browse 2022 Lexus ES listings here.

6. 2021 BMW 5 Series


The BMW 5-Series is the automaker’s second best-selling model, and the 2021 BMW 5-Series is one of the best midsize luxury vehicles on the market. This midsize luxury sedan boasts a spacious interior, state-of-the-art technology, several engine options, and plenty of technology features.


There are four trim levels, including the 530i, 540i, 530e, M550i xDrive, and M5. The 530i comes with a four-cylinder engine, and the 540i has a six-cylinder engine. New for 2021, the 540i gets a boost from a 48-volt hybrid system.

The M550i doesn’t disappoint with a twin-turbocharged 4.4-liter V8. The top-performing M5 has a 4.4-liter BMW M twin power turbo V8 under its hood.

Depending on the model you buy, you’ll have between ten and 14 cubic feet of trunk space. Pricing for the 2021 BMW 5 Series starts at $54,200.

Browse 2021 BMW 5 Series listings here.

7. 2021 Audi A6


The 2021 Audi A6 is the performance-minded and technology-loaded luxury sedan on this list. Its tasteful styling and materials feel upscale for an understated design.

It comes standard with either a 248 horsepower turbocharged 2.0-liter four-cylinder engine or a 335 horsepower turbocharged 3.0-liter V6 engine. Both powertrains use hybrid technology to power the vehicle’s start/stop functions and ancillary equipment.


This vehicle has a seven-speed S Tronic transmission and a host of technological amenities, such as Android Auto, Apple CarPlay, Bluetooth, and Alexa integration. Easily navigate the 8.8-inch display or upgrade to the larger 10.1-inch display. The A6 has a respectable amount of trunk space, measuring 13.7 cubic feet.

Pricing for the 2021 Audi A6 starts at $54,900.

Browse 2021 Audi A6 listings here.

8. 2021 Genesis G80


The 2021 Genesis G80 is one of the best midsize luxury sedans on the market, with a 3.5-liter twin-turbo V6 that’s paired with an eight-speed automatic transmission and is all-wheel-drive. This four-door vehicle comes with an eight-speed automatic transmission and seating for five, and its interior includes heated and ventilated front seats and a 16-way power driver seat.


Keyless entry, lane keep assist, tire pressure warnings, and forward-collision avoidance assist is just a few of this vehicle’s extra features. A standout feature added to the G80 is the remote smart parking assist. Hand over parking to your G80 and let it safely and intelligently park itself in the tightest of spaces. You’ll have plenty of room with the 13.1 cubic feet of cargo space in the trunk. Pricing for the 2021 Genesis G80 starts at $47,700.

Browse 2021 Genesis G80 listings here.

9. 2021 Audi A7


Based on the A6 sedan, the more upscale A7 offers refined composure and sleek profiling. This midsize luxury car blurs the line between sedan and hatchback for a unique body style with plenty of trunk space. It comes standard with an intercooled turbo gas/electric 3.0-liter V6 engine capable of 335 horsepower.


There are five trim levels: Premium, Premium Plus, Premium Plus PHEV, Prestige, and Prestige PHEV. This car also has a wealth of conveniences, including a backup camera, electronic stability control, lane departure warning, and power child safety locks on the rear seats.

Standard features include heated front seats, leather seating throughout, panoramic sunroof, three-zone climate control, and ambient interior lighting. The A7 also has a massive amount of trunk space for your cargo, measuring 24.9 cubic feet. Pricing for the 2021 Audi A7 starts at $69,200.

Browse 2021 Audi A7 listings here.

10. 2022 Mercedes-Benz CLS-Class


Part of the third generation of Mercedes-Benz CLS-Class midsize luxury vehicles, the 2022 Mercedes-Benz CLS-Class has a sleek profile and beautiful interior. Powering the CLS is a turbocharged and intercooled 3.0-liter inline-six capable of producing 362 horsepower. It’s paired with a nine-speed automatic and manual shifting mode.


This luxury car has a wide range of conveniences, including a blind-spot assist, a backup camera, collision prevention assist, and electronic stability control. The giant 12.3-inch infotainment display in the dash sits neatly behind a shared glass panel with the gauge cluster. The controller is mounted on the center control, and it comes programmed with Mercedes’ operating system and robust voice recognition software.

It also has a decent amount of trunk space, as 12 cubic feet. Pricing for the 2021 Mercedes-Benz CLS-Class starts at $74,000.

Browse 2022 Mercedes-Benz CLS-Class listings here.

11. 2021 Infiniti Q50


Though it's getting old, especially compared to the rest of this list, the Q50 looks great with modern styling. New for the 2021 year is the Sensory model with 19-inch wheels, leather upholstery, and a sportier design. There are five models available, the Pure, Luxe, Sensory, Signature Edition, and Red Sport 400.


Giving the Q50 its power is a 300 horsepower twin-turbo V6 and seven-speed automatic. The Red Sport model takes this up a notch with a 3.0-liter V-6 engine with twin turbochargers that deliver 400 horsepower. However, it isn’t as fuel-efficient as the other models. Trunk space is decent on the Q50, measuring 13.2 to 13.5 cubic feet.

Pricing for the 2021 Infiniti Q50 starts at $37,625.

Browse 2021 Infiniti Q50 listings here.